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KMID : 0604520110370010055
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 1 p.55 ~ p.60
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A Study on the Stability of DOPC Liposome
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Won Doo-Hyun
Kim Sun-Young
Lim Gyu-Nam
Park Soo-Nam
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Abstract
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In this study, DOPC liposomes were prepared with distilled water, phosphate buffer and phosphate buffered saline to evaluate the effects of salt on the stability of DOPC liposome. The changes in physical properties (likeparticle size and zeta potential) of liposome were measured after adding the salt. Liposomes were diluted 40 times and 80 times with hydration solvent to confirm the effect of dilution. Consequently, the stability of liposome was maintained up to 40 times dilution with hydration solvent. The liposome that prepared with distilled water was diluted with distilled water, phosphate buffer and phosphate buffered saline, and the liposome that prepared with phosphate buffer was diluted with phosphate buffer and phosphate buffered saline to evaluate the salt-induced changes in particle size and zeta potentia. As results, the particle size increased slightly and zeta potential became closer to 0 when the salt concentration was increased. In conclusion, particle size and zeta potential of liposome could be reasonable factors to evaluate the stability of liposome. In addition, we suggest that salt concentration of hydration solvent has a significant effect on the stability of liposome.
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KEYWORD
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DOPC liposome, zeta potential, particle size, stability, phosphate buffered saline
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